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Ambien is a widespread sleeping drug in the United States, which has recently attracted media attention, especially after such massive night awakenings began to cover more and more people. Sleep and food are the two most necessary things for a person, and, as it turned out, they are also interconnected, because the brain regions responsible for these two functions are located very close to each other. Hormones that control our appetite also affect the sleep cycle. When a person does not get enough sleep, these “general hormones” can have an impact on the appetite. In addition, during sleep, the body begins to produce a substance such as leptin, which suppresses hunger during sleep. Many doctors do not believe that the basic substance Zolpidem, which is contained in Ambien, can in any way cross the functions of sleep and hunger, especially in such low doses that are usually prescribed to patients. Ambien is a hypnotic drug of imidazopyridine structure with a rapidly advancing effect. Unlike benzodiazepines, Ambien (active ingredient Zolpidem) is a selective agonist of the omega1-benzodiazepine receptor subclass.
How Ambien is Used to Treat Insomnia
The pharmaceutical drug zolpidem – sold under the brand names of Ambien, Ambien CR, and Intermezzo – is a commonly prescribed hypnotic medication used to initiate sleep and to treat insomnia. Ambien is a hypnotic drug that has direct effects on the central nervous system, specifically the brain.1 It causes drowsiness and is safe and effective for initiating and maintaining sleep. It is used to treat insomnia or acute insomnia. You may be prescribed a standard or controlled-release (CR) formulation of the drug. There is also a fast-acting form that is taken under the tongue (sublingually). These vary slightly in how long it takes the body to metabolize them, but their effects are the same. Depending on the formulation used, there are different dosages of Ambien. Women, in particular, are advised by the U.S. Food and Drug Administration (FDA) to use lower doses due to the potential risks of morning hangover effects that may impact safe driving.
The doses of the various formulations of zolpidem include the following:
- Ambien: 5 mg or 10 mg
- Ambien CR: 6.25 mg or 12.5 mg
- Intermezzo (sublingual): 1.75 mg or 3.5 mg
How Does It Work?
Ambien promotes the activity of GABA receptors, a special type of neurotransmitter. Neurotransmitters are chemicals that serve as messengers between nerve cells (neurons). The additional activity of the GABA receptors inhibits neuron activity that contributes to insomnia.
Ambien side effects
There are many potential side effects of any drug. At high doses, Ambien may cause amnesia (memory loss), suppression of REM sleep, or breathing difficulties. Abrupt cessation of the medication at higher doses may also cause rebound insomnia. Although an individual likely won’t experience most side effects associated with the drug – and may indeed not have any of them – some that commonly occur include: depression, anxiety, aggression, agitation, confusion, unusual thoughts, hallucinations, memory problems, changes in personality, risk-taking behavior, decreased inhibitions, no fear of danger, or thoughts of suicide or hurting yourself.
Stop using this medicine and call your doctor at once if you have:
trouble breathing or swallowing; or
feeling like you might pass out.
The sedative effect of Ambien may be stronger in older adults.
Dizziness or severe drowsiness can cause falls, accidents, or severe injuries.
Common Ambien side effects may include:
daytime drowsiness, dizziness, weakness, feeling “drugged” or light-headed;
tired feeling, loss of coordination;
stuffy nose, dry mouth, nose or throat irritation;
nausea, constipation, diarrhea, upset stomach; or
headache, muscle pain.
Interactions of Ambien
Using Ambien with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Many drugs can interact with zolpidem, making it less effective or increasing side effects. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval. A product that may interact with this drug is: sodium oxybate. Other medications can affect the removal of zolpidem from your body, which may affect how zolpidem works. Examples include azole antifungals (such as ketoconazole), rifampin, St. John’s Wort, among others.
The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zopiclone), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).