What is Actican (lorazepam)?
Buy Activan ( Lorazepam ) online Lorazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) It is thought that benzodiazepines work by enhancing the activity of certain neurotransmitters in the brain.
Lorazepam is used to treat anxiety disorders.
It is dangerous to purchase lorazepam on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.
Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting. It is also used during surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection onset of effects is between one and thirty minutes and effects last for up to a day.
Common side effects include weakness, sleepiness, low blood pressure, and a decreased effort to breathe. When given intravenously the person should be closely monitored. Among those who are depressed there may be an increased risk of suicide. With long-term use, larger doses may be required for the same effect. Physical dependence and psychological dependence may also occur. If stopped suddenly after long-term use, benzodiazepine withdrawal syndrome may occur. Older people more often develop adverse effects. In this age group lorazepam is associated with falls and hip fractures. Due to these concerns, lorazepam use is generally only recommended for up to two to four weeks.
Lorazepam was initially patented in 1963 and went on sale in the United States in 1977. It is on the World Health Organization’s List of Essential Medicines. It is available as a generic medication. In 2018, it was the 58th most commonly prescribed medication in the United States, with more than 13 million prescriptions.
How to use ACTIVAN (lorazepam)?
Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition, age, and response to treatment.
If you suddenly stop using this medication, you may have withdrawal symptoms (such as seizures, trouble sleeping, mental/mood changes, nausea, vomiting, diarrhea, loss of appetite, stomach pain, hallucinations, numbness/tingling of arms and legs, muscle pain, fast heartbeat, short-term memory loss, very high fever, and increased reactions to noise/touch/light). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used lorazepam regularly for a long time (more than 1-4 weeks) or in high doses or if you have a history of alcoholism, drug abuse, or personality disorder. Tell your doctor or pharmacist right away if you have withdrawal.
Before taking this medicine
You should not take lorazepam if you have:
- narrow-angle glaucoma; or
- a history of allergic reaction to any benzodiazepine (lorazepam, alprazolam, diazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, Xanax, and others).
To make sure lorazepam is safe for you, tell your doctor if you have::
- breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep);
- drug or alcohol addiction;
- depression, mood problems, or suicidal thoughts or behavior;
- kidney or liver disease;
- seizures; or
Tell your doctor if you are pregnant or plan to become pregnant. Lorazepam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.
If you use lorazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
If you are breastfeeding, tell your doctor if you notice drowsiness or fussiness in the nursing baby. Buy Activan ( Lorazepam ) online
Lorazepam is not approved for use by anyone younger than 12 years old.
What are the side effects of Buy Activan ( Lorazepam ) online?
Lorazepam may cause side effects. Call your doctor if any of the following symptoms are severe or do not go away:
- dry mouth
- changes in appetite
- restlessness or excitement
- difficulty urinating
- frequent urination
- blurred vision
- changes in sex drive or ability
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNINGS section, call your doctor immediately or get emergency medical treatment:
- shuffling walk
- persistent, fine tremor or inability to sit still
- severe skin rash
- yellowing of skin or eyes
- irregular heartbeat
Lorazepam may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Lorazepam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet).
Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take lorazepam with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.
Lorazepam may be habit forming. Do not take a larger dose, take it more often, or for a longer time than your doctor tells you to. Tell your doctor if you have ever drunk large amounts of alcohol, if you use or have ever used street drugs, or have overused prescription medications. Do not drink alcohol or use street drugs during your treatment. Drinking alcohol or using street drugs during your treatment with lorazepam also increases the risk that you will experience these serious, life-threatening side effects. Also tell your doctor if you have or have ever had depression or another mental illness. Buy Activan ( Lorazepam ) online
Lorazepam may cause; physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you take it for several days to several weeks. Do not stop taking this medication or take fewer doses without talking to your doctor. Stopping lorazepam suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months.
Your doctor probably will decrease your lorazepam dose gradually. Call your doctor or get emergency medical treatment if you experience any of the following symptoms: unusual movements; ringing in your ears; anxiety; memory problems; difficulty concentrating; sleep problems; seizures; shaking; muscle twitching; changes in mental health; depression; burning or prickling feeling in your hands, arms, legs or feet; seeing or hearing things that others do not see or hear; thoughts of harming or killing yourself or others; overexcitement; or losing touch with reality.
Tolerance and dependence
Dependence typified by a withdrawal syndrome occurs in about one-third of individuals who are treated for longer than four weeks with a benzodiazepine. Higher doses and longer periods of use increase the risk of developing a benzodiazepine dependence. Potent benzodiazepines with a relatively short half life, such as lorazepam, alprazolam, and triazolam, have the highest risk of causing a dependence. Tolerance to benzodiazepine effects develops with regular use. This is desirable with amnesic and sedative effects but undesirable with anxiolytic, hypnotic, and anticonvulsant effects. People initially experience drastic relief from anxiety and sleeplessness, but symptoms gradually return, relatively soon in the case of insomnia, but more slowly in the case of anxiety symptoms. After four to six months of regular benzodiazepine use, evidence of continued efficacy declines.
If regular treatment is continued for longer than four to six months, dose increases may be necessary to maintain effects, but treatment-resistant symptoms may in fact be benzodiazepine withdrawal symptoms. Due to the development of tolerance to the anticonvulsant effects, benzodiazepines are generally not recommended for long-term use for the management of epilepsy. Increasing the dose may overcome tolerance, but tolerance may then develop to the higher dose and adverse effects may persist and worsen. The mechanism of tolerance to benzodiazepines is complex and involves GABAA receptor downregulation, alterations to subunit configuration of GABAA receptors, uncoupling and internalisation of the benzodiazepine binding site from the GABAA receptor complex as well as changes in gene expression. Buy Activan ( Lorazepam ) online
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Buy Activan ( Lorazepam ) online
What happens if I overdose Buy Activan ( Lorazepam ) online?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of lorazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.
Overdose symptoms may include extreme drowsiness, confusion, slurred speech, feeling restless, muscle weakness, loss of balance or coordination, feeling light-headed, slow heartbeats, weak or shallow breathing, or coma.
What should I avoid while taking lorazepam?
Avoid drinking alcohol. Dangerous side effects or death could occur.
Avoid driving or hazardous activity until you know how lorazepam will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Buy Activan ( Lorazepam ) online
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